HIV-2 EHO ISOLATE HAS A DIVERGENT ENVELOPE GENE AND INDUCES SINGLE-CELL KILLING BY APOPTOSIS

被引：30

作者：

REYCUILLE, MA ^{[1
]}

GALABRU, J ^{[1
]}

LAURENTCRAWFORD, A ^{[1
]}

KRUST, B ^{[1
]}

MONTAGNIER, L ^{[1
]}

HOVANESSIAN, AG ^{[1
]}

机构：

[1] INST PASTEUR,DEPT AIDS & RETROVIRUSES,CNRS,UA 1157,F-75015 PARIS,FRANCE

来源：

VIROLOGY | 1994年 / 202卷 / 01期

关键词：

D O I：

10.1006/viro.1994.1364

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human immunodeficiency virus type 2 (HIV-2)-related isolate, referred to as HIV-2 EHO, has been isolated from an Ivory Coast patient with acquired immunodeficiency syndrome (AIDS). Infection of CD4 expressing cells with this highly infectious virus mediates a cytopathic effect characterized by single-cell killing as a consequence of apoptosis. Nucleotide sequence analysis of the HIV-2 EHO genome revealed a significant degree of divergence of its envelope gene from that of other known HIV-2 strains. This divergence for the deduced amino acid sequence corresponding to the extracellular envelope glycoprotein was 26 to 30%. These unique genetic and biological properties suggest that the HIV-2 EHO isolate is a distinct prototype in the HIV-2 family. (C) 1994 Academic Press, Inc.

引用

页码：471 / 476

页数：6

共 29 条

[1] INFECTION OF MACACA-NEMESTRINA BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

AGY, MB ;

FRUMKIN, LR ;

COREY, L ;

COOMBS, RW ;

WOLINSKY, SM ;

KOEHLER, J ;

MORTON, WR ;

KATZE, MG .

SCIENCE, 1992, 257 (5066) :103-106

[2]

ALDOVINI A, 1990, TECHNIQUES HIV RES

[3] GENETIC AND FUNCTIONAL-ANALYSIS OF A SET OF HIV-1 ENVELOPE GENES OBTAINED FROM BIOLOGICAL CLONES WITH VARYING SYNCYTIUM-INDUCING CAPACITIES [J].

ANDEWEG, AC ;

GROENINK, M ;

LEEFLANG, P ;

DEGOEDE, REY ;

OSTERHAUS, ADME ;

TERSMETTE, M ;

BOSCH, ML .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (10) :1803-1813

[4] DISTINGUISHING FEATURES OF AN INFECTIOUS MOLECULAR CLONE OF THE HIGHLY DIVERGENT AND NONCYTOPATHIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 UC1 STRAIN [J].

BARNETT, SW ;

QUIROGA, M ;

WERNER, A ;

DINA, D ;

LEVY, JA .

JOURNAL OF VIROLOGY, 1993, 67 (02) :1006-1014

[5] PARTICIPATION OF TYROSINE PHOSPHORYLATION IN THE CYTOPATHIC EFFECT OF HUMAN-IMMUNODEFICIENCY-VIRUS .1. [J].

COHEN, DI ;

TANI, Y ;

TIAN, H ;

BOONE, E ;

SAMELSON, LE ;

LANE, HC .

SCIENCE, 1992, 256 (5056) :542-545

[6]

DECOCK KM, 1991, AIDS, V5, pS21

[7] DEMONSTRATION OF 2 DISTINCT CYTOPATHIC EFFECTS WITH SYNCYTIUM FORMATION-DEFECTIVE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 MUTANTS [J].

DEDERA, D ;

RATNER, L .

JOURNAL OF VIROLOGY, 1991, 65 (11) :6129-6136

[8] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 CLONES CHIMERIC FOR THE ENVELOPE V3 DOMAIN DIFFER IN SYNCYTIUM FORMATION AND REPLICATION CAPACITY [J].

DEJONG, JJ ;

GOUDSMIT, J ;

KEULEN, W ;

KLAVER, B ;

KRONE, W ;

TERSMETTE, M ;

DERONDE, A .

JOURNAL OF VIROLOGY, 1992, 66 (02) :757-765

[9] A HIGHLY DIVERGENT HIV-2-RELATED ISOLATE [J].

DIETRICH, U ;

ADAMSKI, M ;

KREUTZ, R ;

SEIPP, A ;

KUHNEL, H ;

RUBSAMENWAIGMANN, H .

NATURE, 1989, 342 (6252) :948-950

[10] HUMAN INFECTION BY GENETICALLY DIVERSE SIVSM-RELATED HIV-2 IN WEST AFRICA [J].

GAO, F ;

YUE, L ;

WHITE, AT ;

PAPPAS, PG ;

BARCHUE, J ;

HANSON, AP ;

GREENE, BM ;

SHARP, PM ;

SHAW, GM ;

HAHN, BH .

NATURE, 1992, 358 (6386) :495-499

← 1 2 3 →