ORGANIZATION OF THE HUMAN SEROTONIN TRANSPORTER GENE

被引：554

作者：

LESCH, KP ^{[1
]}

BALLING, U ^{[1
]}

GROSS, J ^{[1
]}

STRAUSS, K ^{[1
]}

WOLOZIN, BL ^{[1
]}

MURPHY, DL ^{[1
]}

RIEDERER, P ^{[1
]}

机构：

[1] NIMH, LCS, CTR CLIN, BETHESDA, MD 20892 USA

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1994年 / 95卷 / 02期

关键词：

HUMAN; SEROTONIN TRANSPORTER; GENE ORGANIZATION; VNTR;

D O I：

10.1007/BF01276434

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning similar to 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

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收藏

页码：157 / 162

页数：6

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