SCALE-UP ENGINEERING IN ANIMAL-CELL TECHNOLOGY .2.

The first part of this article defined what is meant by scale-up. It also introduced the idea that engineers, in seeking to scale up bioprocesses, look at parameters that limit that process. If the parameters are independent of scale or reactor configuration they may enable the calculation of engineering data to predict behavior at large scales. In this exercise, dimensional analysis is one of the engineer's most important tools. In Part II, the authors examine the application of the approach outlined in Part I to the analysis of scale-up in situations where shear or mass transfer may be limiting factors, situations which are particularly likely to arise in animal cell culture.