MONOKINE PRODUCTION BY PERIPHERAL WHOLE-BLOOD IN CHRONIC HEPATITIS-C PATIENTS TREATED WITH INTERFERON

被引：7

作者：

ITOH, Y ^{[1
]}

OKANOUE, T ^{[1
]}

SAKAMOTO, S ^{[1
]}

NISHIOJI, K ^{[1
]}

YASUI, K ^{[1
]}

SAKAMOTO, M ^{[1
]}

KASHIMA, K ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT INTERNAL MED 3,KAMIGYOU KU,KYOTO 602,JAPAN

来源：

DIGESTIVE DISEASES AND SCIENCES | 1995年 / 40卷 / 11期

关键词：

MONOKINE; WHOLE BLOOD; INTERFERON THERAPY; HEPATITIS C;

D O I：

10.1007/BF02063248

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Using our scoring system, we studied the production of monokines (interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-6) by lipopolysaccharide-stimulated peripheral whole blood in 35 patients with chronic hepatitis C during the interferon-alpha/beta therapy, It decreased in 25.7% (9/35, group A), fluctuated in 60.0% (21/35, group B), and increased in 14.3% (5/35, group C). The patients in group A were younger than those in group B (P < 0.05). The histological grade of injury was milder in group A than in group B or C, The rate of sustained response was 66.7% (6/9) in group A, 19.0% (4/21) in group B, and 40.0% (2/5) in group C (P = 0.0184, group A versus group B), In summary, monokine production by peripheral whole blood varied during interferon therapy for chronic hepatitis C patients, No significant change was noted in 60% of the patients. However, patients with decreased monokine production were younger, with a mild histological grade, and likely to respond to the interferon therapy.

引用

页码：2423 / 2430

页数：8

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