SOURCES OF T1 VARIANCE IN NORMAL HUMAN WHITE MATTER

被引:17
作者
HARVEY, I [1 ]
TOFTS, PS [1 ]
MORRIS, JK [1 ]
WICKS, DAG [1 ]
RON, MA [1 ]
机构
[1] INST NEUROL,QUEEN SQ,LONDON WC1N 3BG,ENGLAND
基金
英国医学研究理事会;
关键词
WHITE MATTER; RELAXATION (T1) TIMES; RELIABILITY;
D O I
10.1016/0730-725X(91)90096-5
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The major factors contributing to T1 variance at 0.5 T in white matter were studied in healthy people. Anatomical location of the white matter sampled and differences between individuals contributed 74% of the total variance in serial measurements of the same subjects. There was also significant change over time within an individual subject that could not be attributed to machine drift. This information permitted estimates to be made concerning adequate sample size in future studies that examine for pathological white matter T1 change.
引用
收藏
页码:53 / 59
页数:7
相关论文
共 20 条
[1]  
Miller, Johnson, Tofts, MacManus, McDonald, Precise relaxation time measurements of normal appearing white matter in inflammatory central nervous system disease, Magn. Reson. Med., 11, pp. 331-336, (1989)
[2]  
Christie, Kean, Douglas, Engleman, St. Clair, Blackburn, Magnetic resonance imaging in pre-senile dementia of the Altzheimer type, multi-infarct dementia and Korsakoff's syndrome, Psycholog. Med., 18, pp. 319-329, (1988)
[3]  
Johnson, Ormerod, Barnes, Tofts, McManus, Accuracy and precision in the measurement of relaxation times in NMR images, Br. J. Radiol., 60, pp. 143-153, (1987)
[4]  
Bydder, Young, MR imaging: Clinical use of the inversion recovery sequence, J. Comput. Assist. Tomogr., 9, pp. 659-674, (1985)
[5]  
Johnson, Miller, MacManus, Tofts, Barnes, du Boulay, MacDonald, STIR sequences in NMR imaging of the optic nerve, Neuroradiology, 29, pp. 238-245, (1987)
[6]  
McManus, Kermode, Tofts, A repositioning technique for cerebral magnetic resonance imaging of patients with multiple sclerosis, Society of Magnetic Resonance in Medicine, 8th Annual Meeting, Amsterdam, 2, (1989)
[7]  
Robb, Barillot, Interactive display and analysis of 3-D medical images, IEEE Transactions on Medical Imaging, 8, pp. 217-226, (1989)
[8]  
Tofts, Johnson, Correction for Rayleigh noise in an NMR magnitude image when measuring T<sub>2</sub> at low values of signal to noise ratio, Annual Meeting, pp. 1450-1451, (1986)
[9]  
SAS Institute Inc., SAS User's Guide: Statistics, (1985)
[10]  
Breger, Wehrli, Charles, MacFall, Haughton, Reproduction of relaxation and spin-density parameters in phantoms and human brain measured by MR imaging at 1.5 T, Magn. Reson. Med., 3, pp. 649-662, (1986)