A MONOCLONAL-ANTIBODY AGAINST HLA-A11 AND A24

被引：27

作者：

FOUNG, SKH ^{[1
]}

TAIDI, B ^{[1
]}

NESS, D ^{[1
]}

GRUMET, FC ^{[1
]}

机构：

[1] STANFORD UNIV, MED CTR, SCH MED, DEPT PATHOL, STANFORD, CA 94305 USA

来源：

HUMAN IMMUNOLOGY | 1986年 / 15卷 / 03期

关键词：

D O I：

10.1016/0198-8859(86)90006-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A monoclonal IgG antibody was produced from a mouse immunized with an A11, A24; B27, B44 Epstein-Barr virus transformed B lymphoblastoid cell line. The antibody, A11.1M, by standard lymphocytotoxicity assay, reacts with all cells expressing HLA-A11 and -A24. Absorption studies with both A11+, A24- and A11-, A24+ platelets removed antibody reactivity against A11 and A24 lymphocytes. The shared antigenic determinant between A11 and A24, as defined by this antibody, A11.1M, represents a new "supertypic" determinant.

引用

页码：316 / 319

页数：4

共 6 条

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