CYTOLYTIC TOXINS FROM SEA-ANEMONES

被引:72
作者
TURK, T
机构
[1] Department of Biology Biotechnical, Faculty University of Ljubljana, 61000, Ljubljana
来源
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 1991年 / 10卷 / 03期
关键词
D O I
10.3109/15569549109053857
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
A number of cytolytic toxins are commonly found in sea anemones. They represent a unique class of animal toxins considering their biochemical characteristics and biological activity. Sea anemone cytolysins are lethal polypeptides which act directly at the membrane level and have potent cardiotoxic activity. Cytotoxic, cytocidal and cytostatic activity were also detected. In general they are basic proteins which usually lack Cys or Met residues. Sea anemone cytolysins are slightly hydrophilic molecules which, however, possess large hydrophobic domains which could insert and span across cell membranes and thus form an ion channel. Cytolytic activity of all except one cytolysin can be prevented by sphingomyelin. Purification, biochemical characterization of sea anemone cytolysins and their mechanisms of action are discussed in the following review article.
引用
收藏
页码:223 / 262
页数:40
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