ACID-CATALYZED POLY(ORTHO ESTER) MATRICES FOR INTERMEDIATE TERM DRUG DELIVERY

被引：7

作者：

SHIH, C

LUCAS, S

ZENTNER, GM

机构：

[1] INTERx Research Corporation/Merck Sharp and Dohme Research Laboratories, Lawrence, KS 66047

[2] Department of Pharmaceutical Chemistry, University of Kansas, Lawrence

来源：

JOURNAL OF CONTROLLED RELEASE | 1991年 / 15卷 / 01期

关键词：

BIOERODIBLE POLYMER; POLY(ORTHO ESTER) MATRICES; ACID CATALYZED EROSION; DRUG RELEASE MECHANISM; CONTROLLED RELEASE OF TIMOLOL MALEATE;

D O I：

10.1016/0168-3659(91)90103-K

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The in vitro release of timolol maleate from poly(ortho ester) matrices was studied. Release profiles ranged from simple zero-order to complex multiphasic release patterns. The observed profile was dependent on both the polymer and the catalyst selected. Polymers that contained greater-than-or-equal-to 50 mol% of cyclohexane-trans-1,4-dimethanol (CDM) in the backbone consistently gave linear drug release profiles. Multiphasic drug release profiles were associated with polymers of < 50 mol% of CDM and lipophilic acid catalysts. The nature of the drug release profile was related to the T(g) of the polymer-drug-catalyst composite. A purely surface or bulk erosion-controlled drug release mechanism could not account for the observed drug release profiles. Linear release from devices of varied geometries suggested that diffusion through a rate controlling surface skin layer may be a limiting step in the overall drug release mechanism.

引用

页码：55 / 63

页数：9

共 19 条

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