THE ACUTE EFFECT OF SERTINDOLE ON BRAIN 5-HT2, D2 AND ALPHA-1 RECEPTORS (EXVIVO RADIORECEPTOR BINDING-STUDIES)

The ability of sertindole to influence the ex vivo binding of H-3-ketanserin, H-3-prazosin and H-3-spiperone to 5-HT2 receptors, alpha-1-adrenoceptors and DA D2 receptors, respectively, in rat brain has been studied after acute treatment. Sertindole is a potent, long acting compound which readily passes the blood-brain barrier. It dose-dependently binds to all three receptors types. In line with in vivo behavioural experiments sertindole has the most pronounced effect on 5-HT2 receptors, lower effect on a,-adrenoceptors and the lowest effect on striatal D2 receptors.