LIQUID-CHROMATOGRAPHY ELECTROSPRAY IONIZATION MASS-SPECTROMETRY OF CYANOBACTERIAL TOXINS

被引：74

作者：

POON, GK ^{[1
]}

GRIGGS, LJ ^{[1
]}

EDWARDS, C ^{[1
]}

BEATTIE, KA ^{[1
]}

CODD, GA ^{[1
]}

机构：

[1] UNIV DUNDEE, DEPT BIOL SCI, DUNDEE DD1 4HN, SCOTLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 628卷 / 02期

关键词：

D O I：

10.1016/0021-9673(93)80005-S

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cyanobacterial neurotoxins such as anatoxin-a and saxitoxin, peptide hepatotoxins including microcystin variants and nodularin were studied by electrospray ionization-mass spectrometry following direct infusion of samples into the mass spectrometer. This technique was further exemplified when analysing the cyclic hepatotoxic peptides by means of on-line liquid chromatography-mass spectrometry. Peptide toxins were identified in extracts from toxic bloom material and cell cultures by comparison of spectral and chromatographic data to that of authentic materials. When authentic materials were not available, several peptides were tentatively identified by their molecular-weight information provided by this technique.

引用

页码：215 / 233

页数：19

共 23 条

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[2]

Codd G. A., 1988, Biochemistry of the Algae and Cyanobacteria . Proceedings of The Phytochemical Society of Europe, No 28., P283

[3]

EDWARDS C, 1992, IN PRESS TOXICON

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