SYNTHESIS OF 4-C-HYDROXYMETHYL HEXOPYRANOSYL NUCLEOSIDES AS POTENTIAL INHIBITORS OF HIV

被引：10

作者：

BJORSNE, M

CLASSON, B

KVARNSTROM, I

SAMUELSSON, B

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

[2] ASTRA HASSLE AB,S-43183 MOLNDAL,SWEDEN

[3] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

来源：

TETRAHEDRON | 1993年 / 49卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(01)96269-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1-(2,3,4-trideoxy-4-C-hydroxymethyl-beta-D-erythro-hexopyranosyl)thymine (13), -uracil (15), -cytosine (16) and 9-(2,3,4-trideoxy-4-C-hydroxymethyl-beta-D-erythro-hexopyranosyl)adenine (18) are described. The nucleoside analogues were evaluated for their anti-HIV activity in vitro.

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页码：8637 / 8644

页数：8

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