IDENTIFICATION OF 4 EPITOPES IN HEPATITIS-C VIRUS CORE PROTEIN

被引：28

作者：

FERRONI, P

MASCOLO, G

ZANINETTI, M

COLZANI, D

PREGLIASCO, F

PIRISI, M

BARBONE, F

GASPARINI, V

机构：

[1] UNIV UDINE,DEPT FOOD SCI,I-33100 UDINE,ITALY

[2] UNIV UDINE,HYG & EPIDEMIOL UNIT,I-33100 UDINE,ITALY

[3] UNIV UDINE,DEPT INTERNAL MED,I-33100 UDINE,ITALY

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1993年 / 31卷 / 06期

关键词：

D O I：

10.1128/JCM.31.6.1586-1591.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We identified four epitopes in hepatitis C virus core protein by using the algorithm of Jameson and Wolf. G15V (amino acids [aa] 31 to 45) appears to be the immunodominant epitope, since it was able to detect antibodies to the core protein in all 40 patients and in 44 of 45 recombinant immunoblot assay-confirmed positive blood donors. This epitope is associated with a low frequency of false-positive results, as found with 522 negative blood donors. A strong reactivity was also observed with the Q15V epitope (aa 7 to 21), although this was associated with low specificity. Occasional reactivity to the R15P (aa 49 to 63) and P15R (aa 99 to 113) epitopes was observed. Q15V and G15V detected antibodies to core protein earlier than the other two epitopes.

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页码：1586 / 1591

页数：6

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