Inducing properties of rifabutin, and effects on the pharmacokinetics and metabolism of concomitant drugs

被引：23

作者：

Benedetti, MS

机构：

[1] Pharmacia, Research and Development, Milan

来源：

PHARMACOLOGICAL RESEARCH | 1995年 / 32卷 / 04期

关键词：

enzyme induction; rifabutin; rifampicin; AIDS; tuberculosis;

D O I：

10.1016/S1043-6618(05)80021-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis and treatment of MAC in patients with AIDS. Rifabutin induces cytochrome P-450 3A4. The effect of rifabutin on the pharmacokinetics and metabolism of drugs administered concomitantly to humans (isoniazid, ethambutol, zidovudine, didanosine, delavirdine, fluconazole, itraconazole, methadone, clarithromycin, theophylline and cyclosporin) has been reviewed. (C) 1995 The Italian Pharmacological Society

引用

页码：177 / 187

页数：11

共 48 条

[1]

Ascher David P., 1994, Journal of Pharmacy Technology, V10, P258

[2] ACETYLHYDRAZINE HEPATOTOXICITY [J].

BAHRI, AK ;

CHIANG, CS ;

TIMBRELL, JA .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1981, 60 (03) :561-569

[3] INDUCTION AND AUTOINDUCTION PROPERTIES OF RIFAMYCIN DERIVATIVES - A REVIEW OF ANIMAL AND HUMAN STUDIES [J].

BENEDETTI, MS ;

DOSTERT, P .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1994, 102 :101-105

[4]

BENEDETTI MS, 1995, 1 C EUR ASS CLIN PHA

[5]

BENEDETTI MS, 1991, P 3 INT ISSX M AMST, P295

[6]

BOOBIS AR, IN PRESS ADV DRUG ME

[7]

BORIN MT, 1994, 34 INTSC C ANT AG CH, P81

[8]

BORIN MT, 1994, 34 INT C ANT AG CHEM, P82

[9]

Breda M., 1992, Drug Metabolism and Drug Interactions, V10, P323

[10]

BRUGHERA M, 1995, EXP TOXICOL PATHOL, V47, P1

← 1 2 3 4 5 →