ENDOTHELIN RECEPTORS IN CULTURED RENAL EPITHELIAL-CELLS

被引：25

作者：

NEUSER, D

ZAISS, S

STASCH, JP

机构：

[1] Institute of Pharmacology, Bayer AG, 5600 Wuppertal 1

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 02期

关键词：

Ca[!sup]2+[!/sup] (intracellular); Endothelin; LLC-PK[!sub]1[!/sub] cells; MDCK cells; Renal reabsorption;

D O I：

10.1016/0014-2999(90)90536-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We demonstrated the presence of specific binding sites for endothelin in the renal epithelial cell lines. MDCK and LLC-PK1. Endothelin binding induced mobilisation of intracellular calcium, as shown by an increase in 45Ca2+ efflux. This suggests a direct effect of endothelin on renal reabsorption in addition to the effects on the renal vasculature. © 1990.

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页码：241 / 243

页数：3

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