EFFECTS OF HUMIDITY AND TEMPERATURE ON IN-VITRO DISSOLUTION OF CARBAMAZEPINE TABLETS

被引：19

作者：

WANG, JT

SHIU, GK

TING, OC

VISWANATHAN, CT

SKELLY, JP

机构：

[1] US FDA,OFF GENER DRUGS,200 C ST,SOUTH WEST,WASHINGTON,DC 20204

[2] US FDA,BIOPHARMACEUT RES BRANCH,WASHINGTON,DC 20204

[3] US FDA,OFF RES RESOURCES,ROCKVILLE,MD 20857

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1993年 / 82卷 / 10期

关键词：

D O I：

10.1002/jps.2600821006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The rate and extent of dissolution of various approved marketed carbamazepine (CBZ) tablets exposed to 33, 52, 75, and 97% relative humidities at both room temperature and 40-degrees-C, and saturated water vapor at room temperature were compared to fresh unstressed tablets. The dissolution data indicate that exposure of CBZ tablets to high humidity and temperature can have a profound effect on tablet disintegration and dissolution. The dissolution rates of some batches of CBZ products exposed to 97% humidity at 40-degrees-C or saturated water vapor at room temperature were drastically reduced in only 6-7 days.

引用

页码：1002 / 1005

页数：4

共 14 条

[1]

Garner W. E., 1955, CHEM SOLID STATE, P213

[2]

HANSON WA, 1979, PHARM TECH, V3, P45

[3] PHARMACOKINETICS AND DISSOLUTION OF 2 CRYSTALLINE FORMS OF CARBAMAZEPINE [J].