THYROID AND MYOCARDIAL-FUNCTION AFTER REPLACEMENT OF CARBAMAZEPINE BY OXCARBAZEPINE

被引：51

作者：

ISOJARVI, JIT

AIRAKSINEN, KEJ

MUSTONEN, JN

PAKARINEN, AJ

RAUTIO, A

PELKONEN, O

MYLLYLA, VV

机构：

[1] UNIV OULU,DEPT CARDIOL,SF-90220 OULU,FINLAND

[2] UNIV OULU,DEPT CLIN CHEM,SF-90220 OULU,FINLAND

[3] UNIV OULU,DEPT PHARMACOL & TOXICOL,SF-90220 OULU,FINLAND

来源：

EPILEPSIA | 1995年 / 36卷 / 08期

关键词：

CARBAMAZEPINE; OXCARBAMAZEPINE; THYROID HORMONES; MYOCARDIAL FUNCTION;

D O I：

10.1111/j.1528-1157.1995.tb01619.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We determined changes in serum concentrations of thyroid hormones during carbamazepine (CBZ) therapy during a 5-year prospective follow-up study of 20 patients with newly diagnosed epilepsy. In addition, we evaluated the effects of replacing CBZ with oxcarbazepine (OCBZ) in 12 male patients with epilepsy in a 6-month prospective follow-up study. Circulating thyroxine and free thyroxine levels decreased after 2-month CBZ treatment and remained at a low level during the 5-year follow-up. There were no associated changes in serum thyrotropin (TSH) concentrations. When CBZ was replaced by OCBZ, the function of the liver's P450 enzyme system normalized, as shown by an increase in antipyrine(T1/2), and a decrease in antipyrine(CL). Serum total and free thyroxine levels increased, and thereafter serum TSH levels decreased. Indexes of diastolic heart function improved concomitantly, which may reflect subclinical hypothyroidism at the cellular level during CBZ treatment. We conclude that normal thyroid function can be restored in patients with epilepsy by replacing CBZ with OCBZ.

引用

页码：810 / 816

页数：7

共 24 条

[1]

Isojarvi JIT, Pakarinen AJ, Ylipalosaari PJ, Myllyla VV, Serum hormones in male epileptic patients receiving anticonvulsant medication, Archives of Neurology, 47, pp. 670-676, (1990)

[2]

Isojarvi JIT, Laatikainen TJ, Pakarinen AJ, Juntunen KTS, Myllyla VV, Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy, N Engl J Med, 329, pp. 383-388, (1993)

[3]

Fichsel H, Knopfle G., Effects of anticonvulsant drugs on thyroid hormones in epileptic children, Epilepsia, 19, pp. 323-336, (1978)

[4]

Liewendahl K, Majuri H, Helenius T., Thyroid function tests in patients on long‐term treatment with various anticonculsant drugs, Clin Endocrinol, 8, pp. 185-191, (1978)

[5]

Yeo PPB, Bates D, Howe JG, Et al., Anticonvulsants and thyroid function, Br. Med J, 1, pp. 1581-1583, (1978)

[6]

Isojarvi JIT, Pakarinen AJ, Myllyla VV, Thyroid function in epileptic patients treated with carbamazepine, Archives of Neurology, 46, pp. 1175-1178, (1989)

[7]

Connell JMC, Rapeport WG, Gordon S, Brodie MJ, Changes in circulating thyroid hormones during short‐term hepatic enzyme induction with carbamazepine, Eur J Clin Pharmacol, 26, pp. 453-456, (1984)

[8]

Isojarvi JIT, Airaksinen KEJ, Repo M, Pakarinen AJ, Salmela P, Myllyla VV, Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients, Journal of Neurology, Neurosurgery & Psychiatry, 56, pp. 710-712, (1993)

[9]

Aanderud S, Myking OL, Strandjord RE, The influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine, Clin Endocrinol, 15, pp. 247-252, (1981)

[10]

Bough EW, Crowley WF, Ridgway EC, Et al., Myocardial function in hypothyroidism. Relation to disease severity and response to treatment, Arch Intern Med, 138, pp. 1476-1480, (1978)

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