KN-62, AN INHIBITOR OF CA2+/CALMODULIN KINASE-II, ATTENUATES CIRCADIAN RESPONSES TO LIGHT

被引:44
作者
GOLOMBEK, DA
RALPH, MR
机构
[1] Department of Psychology, University of Toronto, Toronta, ON
关键词
CIRCADIAN RHYTHMS; PHASE SHIFTS; CAM KINASE II; KN-62; CREB;
D O I
10.1097/00001756-199408150-00024
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
EXPRESSION of immediate early genes and phosphorylation of the transcription factor CREB are induced in the suprachiasmatic nucleus after light pulses that cause phase shifts of circadian rhythms. To test for a direct role of this signalling pathway in mediating circadian responses to light in hamsters, we used KN-62 to inhibit the activity of CaM kinase II (known to phosphorylate CREB) prior to giving light pulses at times that would normally induce phase shifts. Central administration of KN-62 significantly inhibited phase delays and advances induced by bright pulses of light. The data support a model for photic responses of the circadian clock in the SCN that includes the phosphorylation of CREB by activation of CaM kinase II.
引用
收藏
页码:1638 / 1640
页数:3
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