ALTERED RNA TURNOVER IN CARCINOGENESIS - THE DIAGNOSTIC POTENTIAL OF MODIFIED BASE EXCRETION

被引:21
作者
MARVEL, CC
DELROWE, J
BREMER, EG
MOSKAL, JR
机构
[1] UNIV SO CALIF,SO CALIF CANC CTR,DEPT RADIAT ONCOL,LOS ANGELES,CA 90089
[2] CHICAGO INST NEUROSURG & NEURORES,CHICAGO,IL
[3] MONTEFIORE MED CTR,DEPT RADIAT ONCOL,BRONX,NY 10467
关键词
URINARY NUCLEOSIDES; URINARY EXCRETION; MODIFIED NUCLEOSIDES; TUMOR MARKERS; RNA; TRANSFER-RNA; PSEUDOURIDINE;
D O I
10.1007/BF02815361
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Excretion of urinary modified nucleosides is frequently elevated in patients with oncogenic disease. Increases of urinary pseudouridine excretion are now demonstrated in patients with a variety of brain tumors. The potential use of urinary modified base excretion as a cancer marker is discussed and possible sources of the elevated nucleosides are detailed. The specific steps in RNA metabolism that result in increased levels of RNA nucleoside excretion are poorly understood. This knowledge will be necessary to understand the molecular mechanism and the clinical significance of urinary nucleoside excretion in treatment and diagnosis of oncogenic disease.
引用
收藏
页码:353 / 368
页数:16
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