RELATIONSHIP BETWEEN SERUM TESTOSTERONE AND SEX HORMONE-BINDING GLOBULIN IN ADULT MEN WITH INTACT OR ABSENT GONADAL-FUNCTION

被引：21

作者：

CARLSTROM, K

ERIKSSON, A

STEGE, R

RANNEVIK, G

机构：

[1] KAROLINSKA INST,DEPT UROL,S-14186 HUDDINGE,SWEDEN

[2] FERTIL RES INST,MALMO,SWEDEN

来源：

INTERNATIONAL JOURNAL OF ANDROLOGY | 1990年 / 13卷 / 01期

关键词：

gonadal function; men; SHBG; testosterone;

D O I：

10.1111/j.1365-2605.1990.tb00961.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

Serum levels of testosterone and sex hormone‐binding globulin (SHBG) were determined in 80 apparently healthy men aged 25–85 years and in 23 patients with prostatic carcinoma (CAP) aged 60–75 years before and 6 months after orchidectomy. Serum levels of testosterone and SHBG were correlated positively in healthy men, in all subjects overall as well as within different age groups, and in CAP patients before, but not after, orchidectomy. These data are not consistent with the classical theory regarding SHBG regulation and also speak against an influence of SHBG binding on testosterone metabolism as a mechanism behind the observed positive association between testosterone levels and SHBG. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

收藏

页码：67 / 73

页数：7

相关论文

共 24 条

[1] SEX-HORMONE-BINDING GLOBULIN [J].

ANDERSON, DC .

CLINICAL ENDOCRINOLOGY, 1974, 3 (01) :69-96

[2] HORMONE BLOOD-LEVELS AND THEIR INTERRELATIONSHIPS IN NORMAL MEN AND MEN WITH BENIGN PROSTATIC HYPERPLASIA (BPH) [J].

BARTSCH, W ;

BECKER, H ;

PINKENBURG, FA ;

KRIEG, M .

ACTA ENDOCRINOLOGICA, 1979, 90 (04) :727-736

[3] LEVELS OF PLASMA STEROID GLUCURONIDES IN INTACT AND CASTRATED MEN WITH PROSTATIC-CANCER [J].

BELANGER, A ;

BROCHU, M ;

CLICHE, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) :812-815

[4] PROGRESSIVE INCREASE IN NONSEX HORMONE-BINDING GLOBULIN-BOUND TESTOSTERONE FROM INFANCY TO LATE PREPUBERTY IN BOYS [J].

BELGOROSKY, A ;

RIVAROLA, MA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (03) :482-485

[5] NON-SEX HORMONE-BINDING GLOBULIN-BOUND TESTOSTERONE AS A MARKER FOR HYPERANDROGENISM [J].

CUMMING, DC ;

WALL, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (05) :873-876

[6] A SIMPLE 2-STEP PROCEDURE FOR THE SIMULTANEOUS ISOLATION OF CORTICOSTEROID BINDING GLOBULIN AND SEX-HORMONE BINDING GLOBULIN FROM HUMAN-SERUM BY CHROMATOGRAPHY ON CORTISOL-SEPHAROSE AND PHENYL-SEPHAROSE [J].

FERNLUND, P ;

LAURELL, CB .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1981, 14 (06) :545-552

[7] RADIOIMMUNOASSAY OF HUMAN SEX-HORMONE BINDING GLOBULIN - IMPROVED RADIOIODINATION PROCEDURE [J].

FERNLUND, P ;

GERSHAGEN, S ;

LARSSON, I ;

RANNEVIK, G .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1985, 45 (05) :461-469

[8]

FIET J, 1987, PROSTATE CANCER A, P33

[9] RELATIONSHIPS BETWEEN OESTRADIOL-17-BETA, TESTOSTERONE, DIHYDROTESTOSTERONE AND 5-ALPHA-ANDROSTANE-3-ALPHA, 17-BETA-DIOL IN HUMAN BENIGN HYPERTROPHY AND CARCINOMA OF THE PROSTATE [J].

GHANADIAN, R ;

PUAH, CM .

JOURNAL OF ENDOCRINOLOGY, 1981, 88 (02) :255-262

[10] DIET AND SERUM SEX-HORMONES IN HEALTHY-MEN [J].

HAMALAINEN, E ;

ADLERCREUTZ, H ;

PUSKA, P ;

PIETINEN, P .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1984, 20 (01) :459-464