NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS DISCRIMINATE SUBTYPES OF I-125 ANGIOTENSIN-II BINDING-SITES IN THE RAT-BRAIN

被引：81

作者：

GEHLERT, DR

GACKENHEIMER, SL

REEL, JK

LIN, HS

STEINBERG, MI

机构：

[1] Central Nervous System and Cardiovascular Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 01期

关键词：

(Rat); Angiotensin II binding sites (subtypes); Autoradiography; Brain; DuP; 753; WL; 19;

D O I：

10.1016/0014-2999(90)90348-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have utilized quantitative autoradiography to define subtypes of 125I-angiotensin II (AII) binding in rat brain. AII-1 binding (displaced by DuP 753) was found in the nucleus of the solitary tract and the hypothalamus, while AII-2 binding (displaced by WL 19) was found in the thalamus and lateral septum. These results indicate that subtypes of the AII receptor are present in the brain and the AII-1 receptor subtype is present in regions consistant with the known actions of angiotensin. © 1990.

引用

页码：123 / 126

页数：4

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