NO EFFECT OF PULSED MAGNETIC STIMULATION ON THE BLOOD-BRAIN-BARRIER IN RATS

被引：13

作者：

RAVNBORG, M

KNUDSEN, GM

BLINKENBERG, M

机构：

[1] Department of Neurology, N2081, Rigshopitalet, Blegdamsvej 9

来源：

NEUROSCIENCE | 1990年 / 38卷 / 01期

关键词：

D O I：

10.1016/0306-4522(90)90392-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The impact of transcranial pulsed magnetic stimulation on blood-brain barrier permeability was studied in rats. An integral uptake technique was used to assess the blood-brain barrier permeability to the tracers [3H]sucrose, [14C]urea, and 36Cl-. From the arterial plasma concentration-time curve-integral the permeability surface-area products were calculated. A Dantec magnetic stimulator delivering a peak magnetic field of 1.9 T with a rise-time of 160 μs was used for transcranial stimulation of the rats. One group of rats had about 50-60 stimulations during the 15-min infusion of the tracers while another group was exposed to 50 magnetic stimulations a day for one week. A third group comprised the controls. No differences in permeability surface-area product were found for any of the three tracers in the rats exposed to magnetic stimulation as compared with the controls. It is concluded that with regard to blood-barrier integrity, pulsed magnetic stimulation of the brain can be regarded as safe. © 1990.

引用

页码：277 / 280

页数：4

共 14 条

[1]

AGNEW WF, 1987, NEUROSURGERY, V20, P143

[2] MORPHOLOGIC CHANGES AFTER PROLONGED ELECTRICAL-STIMULATION OF THE CATS CORTEX AT DEFINED CHARGE-DENSITIES [J].