PROBING PROTEIN CONFORMATION BY A COMBINATION OF ELECTROSPRAY MASS-SPECTROMETRY AND MOLECULAR MODELING

被引:17
作者
BROWN, C [1 ]
CAMILLERI, P [1 ]
HASKINS, NJ [1 ]
SAUNDERS, M [1 ]
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND
关键词
D O I
10.1039/c39920000761
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Electrospray-ionisation mass spectrometry and molecular modelling have been used to probe two conformations of tuna cytochrome c; the number of protons which could be exchanged by deuterons was in remarkable agreement with that calculated using an algorithm for the determination of solvent-accessible surface.
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页码:761 / 764
页数:4
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