3-DIMENSIONAL H-1 SPECTROSCOPIC IMAGING OF CEREBRAL METABOLITES IN THE RAT USING SURFACE COILS

被引：14

作者：

FERNANDEZ, EJ

MAUDSLEY, AA

HIGUCHI, T

WEINER, MW

机构：

[1] Department of Radiology, University of California, San Francisco

[2] Department of Medicine, University of California, San Francisco

[3] Department of Veterans Affairs Medical Center, San Francisco

来源：

MAGNETIC RESONANCE IMAGING | 1992年 / 10卷 / 06期

关键词：

H-1; SPECTROSCOPY; SPECTROSCOPIC IMAGING; METABOLITE MAPPING; RAT BRAIN; SURFACE COIL;

D O I：

10.1016/0730-725X(92)90451-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Three dimensional metabolite maps of protonated metabolites were obtained using H-1 magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9-30 mul from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat.

引用

页码：965 / 974

页数：10

共 28 条

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