CHRONIC L-ALPHA-GLYCERYL-PHOSPHORYL-CHOLINE INCREASES INOSITOL PHOSPHATE FORMATION IN BRAIN-SLICES AND NEURONAL CULTURES

被引：13

作者：

ALEPPO, G ^{[1
]}

NICOLETTI, F ^{[1
]}

SORTINO, MA ^{[1
]}

CASABONA, G ^{[1
]}

SCAPAGNINI, U ^{[1
]}

CANONICO, PL ^{[1
]}

机构：

[1] UNIV PAVIA,SCH DENT,CHAIR PHARMACOL,PAVIA,ITALY

来源：

PHARMACOLOGY & TOXICOLOGY | 1994年 / 74卷 / 02期

关键词：

D O I：

10.1111/j.1600-0773.1994.tb01082.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Repeated, but not single injections of L-alpha-glyceryl-phosphorylcholine (alpha GPC) significantly increased basal [H-3]inositol monophosphate (InsP) formation in hippocampal, cortical, and striatal slices of male rats. The effect was dose-dependent and was accompanied by an increased incorporation of [H-3]inositol into the phospholipid fraction. Incubation of brain slices with different neurotransmitter antagonists, such as atropine, prazosin, or L-2-amino-4-phosphonobutanoate (L-AP4) did not modify the increase in [H-3]InsP formation produced by alpha GPC, suggesting that the effect is not mediated by an increased availability of a specific neurotransmitter. Similar results were obtained in cerebellar and cortico-striatal neurones in primary culture exposed to daily addition of alpha GPC since the second day of maturation in vitro. We suggest that alpha GPC treatment may result in an increased rate of phospholipid synthesis, including the phosphoinositides available for signal transduction at central nervous system level.

引用

页码：95 / 100

页数：6

共 42 条

[1] ABSORPTION, TISSUE DISTRIBUTION AND EXCRETION OF RADIOLABELED COMPOUNDS IN RATS AFTER ADMINISTRATION OF [C-14] L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE [J].