Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in-situ hybridization

被引:9
作者
Cheville, JC
Bromley, C
Argenyl, ZB
机构
[1] UNIV IOWA HOSP & CLIN,IOWA COLL MED,DEPT PATHOL,DERMATOPATHOL UNIT,IOWA CITY,IA 52242
[2] UNIV IOWA HOSP & CLIN,IOWA COLL MED,DEPT DERMATOL,IOWA CITY,IA 52242
关键词
D O I
10.1111/j.1600-0560.1995.tb01149.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Keratoacanthoma (KA) is generally considered to be a clinically and histologically distinct entity, but it often remains difficult to separate from well-differentiated squamous cell carcinoma (WDSCC). Recently, trisomy 7 has been identified in squamous cell carcinoma of the skin. In this study, we examined classical KA (n=6), WDSCC (n=8) and squamous cell carcinoma with KA-like features (SCC-KA) (n=8) for trisomy 7 by fluorescence in-situ hybridization (FISH) to determine if this chromosomal abnormality is unique to squamous lesions diagnosed as WDSCC, or shared by both KA and SCC. In addition, the pertinent clinical-histopathologic findings were summarized. Trisomy 7 was identified in one KA, one SCC-KA and two WDSCC. This study by KA and SCC, providing further evidence that KA is most likely a form of SCC. Further studies are required to determine if trisomy 7 in these lesions is of prognostic significance.
引用
收藏
页码:546 / 550
页数:5
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