PHASE-I TOXICITY AND PHARMACOLOGY STUDY OF TRIMETHYLCOLCHICINIC ACID IN PATIENTS WITH ADVANCED MALIGNANCIES

被引：10

作者：

HU, E

KO, R

KODA, R

ROSEN, P

JEFFERS, S

SCHOLTZ, M

MUGGIA, F

机构：

[1] UNIV SO CALIF, SCH MED, DEPT HEMATOL ONCOL, LOS ANGELES, CA 90057 USA

[2] UNIV SO CALIF, SCH PHARM, LOS ANGELES, CA 90057 USA

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1990年 / 26卷 / 05期

关键词：

D O I：

10.1007/BF02897294

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A phase I study of trimethylcolchicinic acid (TMCA) given orally once daily for 5 days every 3rd week was performed in 19 patients with advanced malignancies. Myelosuppression and mucositis were the major toxicities observed. Serum TMCA levels were monitored and appear to be useful in predicting toxicities. A partial response was seen in one lymphoma patient and stabilization of disease was noted in one patient each with prostatic and ovarian cancer. © 1990 Springer-Verlag.

引用

页码：359 / 364

页数：6

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