IDENTIFICATION OF DINR, A DNA DAMAGE-INDUCIBLE REGULATOR GENE OF BACILLUS-SUBTILIS

被引:56
作者
RAYMONDDENISE, A [1 ]
GUILLEN, N [1 ]
机构
[1] INST PASTEUR,INSERM,U199,UNITE PATHOGENIE MICROBIENNE MOLEC,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
关键词
D O I
10.1128/jb.173.22.7084-7091.1991
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A Bacillus subtilis strain deficient in homologous recombination was isolated from a library of Tn917lac insertion mutants. The interrupted locus consists of an open reading frame encoding a 22,823-dalton polypeptide. Analysis of the deduced amino acid sequence revealed 34% identity and 47.3% similarity with the LexA protein from Escherichia coli. The gene was designated dinR. It is located between the recA and thyA genetic markers, at 162-degrees on the B. subtilis chromosome. The dinR gene was shown to be expressed during the entire B. subtilis cellular cycle with at least a threefold increase when cells develop competence. In addition, the use of a merodiploid strain, in which a copy of the wild-type dinR gene coexists with a dinR-lacZ transcriptional fusion, demonstrated that dinR is an SOS gene and that the SOS-induced expression of dinR occurred only when a wild-type copy of dinR was present. In addition, DinR seems to regulate the expression of dinC, another SOS gene.
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页码:7084 / 7091
页数:8
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