UAG READTHROUGH IS NOT INCREASED INVIVO BY MOLONEY MURINE LEUKEMIA-VIRUS INFECTION

被引：5

作者：

BERTEAUX, V

ROUSSET, JP

CASSAN, M

机构：

[1] UNIV PARIS 11,FIDELITE TRADUCT & DIFFERENCIAT CELLULAIRE GRP,CNRS,URA 1354,F-91405 ORSAY,FRANCE

[2] INST PASTEUR,UNITE GENET DIFFERENCIAT,CNRS,URA 1149,F-75724 PARIS 15,FRANCE

来源：

BIOCHIMIE | 1991年 / 73卷 / 10期

关键词：

READTHROUGH; VIRUS INFECTION; TRANSLATION; LUCIFERASE;

D O I：

10.1016/0300-9084(91)90091-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of the pol gene of the murine leukemia viruses is subject to translational control at the UAG termination codon of the upstream gene gag. Previous experiments have suggested that: i) Moloney murine leukemia virus infection induces a tRNA(Gln)iii) in an in vitro system using the tobacco mosaic virus as template, this tRNA is able to increase readthrough at the UAG codon [1]. Here we demonstrate that, in vivo, Moloney murine leukemia virus infection does not increase translational readthrough at either the tobacco mosaic virus or the Moloney murine leukemia virus UAG stop codons.

引用

页码：1291 / 1293

页数：3

共 23 条

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