PREFERRED USAGE OF SPECIFIC IMMUNOGLOBULIN GENE SEGMENTS IN CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS OF 3 HLA-IDENTICAL SISTERS

被引：11

作者：

HAKIM, I

AMARIGLIO, N

BROKSIMONI, F

BERKOWITZ, M

ROSNER, E

KNELLER, A

HULU, N

RAMOT, B

BENBASSAT, I

SILVERMAN, GJ

RECHAVI, G

机构：

[1] TEL AVIV UNIV,CHAIM SHEBA MED CTR,SACKLER SCH MED,INST HAEMATOL,IL-56261 TEL HASHOMER,ISRAEL

[2] UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 91卷 / 04期

关键词：

IMMUNOGLOBULIN GENE SEGMENTS; CLL; HLA ANTIGEN;

D O I：

10.1111/j.1365-2141.1995.tb05409.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report three family members, including a set of identical twins, who developed CD5 positive B-CLL. The patients are female Ashkenazi Jews sharing an identical HLA mal studies suggest a process of clonal evolution in one of the phenotype. Two of the HLA loci (B35 and Cw4) were twins. common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL, The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related V-H regions belonging to the V-H(3) subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.

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收藏

页码：915 / 917

页数：3

相关论文

共 12 条

[1] CONTENT AND ORGANIZATION OF THE HUMAN IG VH LOCUS - DEFINITION OF 3 NEW VH FAMILIES AND LINKAGE TO THE IG CH LOCUS [J].

BERMAN, JE ;

MELLIS, SJ ;

POLLOCK, R ;

SMITH, CL ;

SUH, H ;

HEINKE, B ;

KOWAL, C ;

SURTI, U ;

CHESS, L ;

CANTOR, CR ;

ALT, FW .

EMBO JOURNAL, 1988, 7 (03) :727-738

[2]

CUTTNER J, 1992, BLOOD, V80, pA476

[3] IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION FAMILY USAGE IS INDEPENDENT OF TUMOR-CELL PHENOTYPE IN HUMAN-B LINEAGE LEUKEMIAS [J].

DEANE, M ;

NORTON, JD .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (10) :2209-2217

[4] EXPRESSION OF MEMBERS OF THE IMMUNOGLOBULIN-V(H)3 GENE FAMILIES IS NOT RESTRICTED AT THE LEVEL OF INDIVIDUAL GENES IN HUMAN CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

EBELING, SB ;

SCHUTTE, MEM ;

AKKERMANSKOOLHAAS, KE ;

BLOEM, AC ;

GMELIGMEYLING, FHJ ;

LOGTENBERG, T .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (03) :313-320

[5] CHRONIC LEUKEMIAS [J].

FINCH, SC ;

LINET, MS .

BAILLIERES CLINICAL HAEMATOLOGY, 1992, 5 (01) :27-56

[6]

HAKIM I, 1994, ISRAEL J MED SCI, V30, P7

[7] A NEW HUMAN IMMUNOGLOBULIN-VH FAMILY PREFERENTIALLY REARRANGED IN IMMATURE B-CELL TUMORS [J].

HUMPHRIES, CG ;

SHEN, A ;

KUZIEL, WA ;

CAPRA, JD ;

BLATTNER, FR ;

TUCKER, PW .

NATURE, 1988, 331 (6155) :446-449

[8] DEVELOPMENTALLY RESTRICTED IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION GENE EXPRESSED AT HIGH-FREQUENCY IN CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

KIPPS, TJ ;

TOMHAVE, E ;

PRATT, LF ;

DUFFY, S ;

CHEN, PP ;

CARSON, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5913-5917

[9] AUTOANTIBODY-ASSOCIATED KAPPA-LIGHT CHAIN VARIABLE REGION GENE EXPRESSED IN CHRONIC LYMPHOCYTIC-LEUKEMIA WITH LITTLE OR NO SOMATIC MUTATION - IMPLICATIONS FOR ETIOLOGY AND IMMUNOTHERAPY [J].

KIPPS, TJ ;

TOMHAVE, E ;

CHEN, PP ;

CARSON, DA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (03) :840-852

[10] RETINOBLASTOMA GENE DELETIONS IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

LIU, Y ;

GRANDER, D ;

SODERHALL, S ;

JULIUSSON, G ;

GAHRTON, G ;

EINHORN, S .

GENES CHROMOSOMES & CANCER, 1992, 4 (03) :250-256