EFFECTS OF CHRONIC DIETARY ALUMINUM ON LOCAL CEREBRAL GLUCOSE-UTILIZATION IN RATS

被引:7
作者
CLAUBERG, M
SMITH, CB
DANG, T
SOKOLOFF, L
JOSHI, JG
机构
[1] UNIV TENNESSEE,DEPT BIOCHEM,KNOXVILLE,TN 37996
[2] US PHS,NIMH,CEREBRAL METAB LAB,BETHESDA,MD 20892
关键词
ALUMINUM; AGING; C-14] DEOXYGLUCOSE;
D O I
10.1016/0197-4580(94)00061-1
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Beginning at 4 weeks of age normal, mate, Sprague-Dawley rats were reared on Purina Laboratory Chow and drinking water containing 100 mu M ALCL(3). After 2 years, local rates of cerebral glucose utilization were determined with the autoradiographie [14C] deoxyglucose method in the brain as a whole and in 25 brain regions in 6 treated rats and 4 age-matched controls. The results indicate that any effects of chronic aluminum in the diet on rates of cerebral glucose utilization are small. In the brain as a whole, the mean rate of glucose utilization in the aluminum-treated rats was 6% lower than that of the controls (p = 0.09). In 21 of the 25 brain regions examined mean rates of glucose utilization were generally lower in the aluminum-treated rats but in none of the regions were the effects statistically significant.
引用
收藏
页码:657 / 661
页数:5
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