LIPID AND APOLIPOPROTEIN LEVELS AND ENTERAL NUTRITION IN VERY-LOW-BIRTH-WEIGHT PRETERM INFANTS

Lipid, lipoprotein cholesterol and apolipoprotein A-I, A-II and B levels were determined in 10 very low-birth-weight (birth weight 1279 +/- 144 g; gestational age 29.2 +/- 1.2 weeks, mean +/- SD) preterm infants on postnatal days 3, 10 and 21. Feeding with pooled human milk began on day 3 +/- 1 and by day 10 all infants were exclusively enterally fed. Both triglyceride and total cholesterol levels increased significantly from day 3 to day 10 (0.84 +/- 0.28 versus 1.53 +/- 0.72 and 2.42 +/- 0.47 versus 3.24 +/- 0.80, mmol/l, respectively) (p<0.01); thereafter no further increase was observed. The increase in total cholesterol level was primarily due to a significant enhancement of very low-density lipoprotein and low-density lipoprotein cholesterol (1.52 +/- 0.34 versus 2.29 +/- 0.73 mmol/l, p<0.01). Apo A-I, A-II and B levels did not change between day 3 and day 10. From day 10 to day 21, however, a significant increase in apo A-I concentration was noted (0.57 +/- 0.20 versus 0.87 +/- 0.17 g/l, p<0.01), whereas apo A-II levels increased significantly from day 3 to 21 (0.15 +/- 0.03 versus 0.27 +/- 0.08 g/l, p<0.01). No change in apo B level was seen.