HYDROXY-DIRECTED HYDROALUMINATIONS - A STEREOSELECTIVE APPROACH TO CYCLOALKANOLS FROM BETA-ARYL ENONES

被引：15

作者：

KOCH, K

SMITROVICH, JH

机构：

[1] Pfizer Inc., Central Research, Groton

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 08期

关键词：

D O I：

10.1016/0040-4039(94)88006-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various aryl substituted enones are reduced using lithium aluminum hydride to afford sterioselectively trans substituted alkanols. Mechanistic studies demonstrate 1,2 addition followed by hydroxy-directed hydroalumination of the conjugated styryl unit.

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页码：1137 / 1140

页数：4

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