COMPARISON OF METHODS OF ESTIMATING THE MOTHER-TO-CHILD TRANSMISSION RATE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)

被引：17

作者：

MATHESON, PB

WEEDON, J

CAPPELLI, M

ABRAMS, EJ

SHAFFER, N

BAMJI, M

KRASINSKI, K

LAMBERT, G

KAUL, A

GRIMM, K

HUTSON, D

THOMAS, PA

DOBROSYCKI, J

DAVILA, S

GRANT, D

HAND, I

HARRIS, A

JOHNSTON, B

NIEVES, M

SOLOMAN, L

WIZNIA, A

BROTMAN, R

BLANCH, S

BRUTUS, J

DAY, C

RHINEHART, W

SIMON, R

TURKELL, V

GEORGE, R

KALISH, M

KILBOURNE, B

OU, CY

PETZELT, J

RAPIER, J

ROGERS, M

SCHABLE, C

SMITH, L

STRAUS, W

ANDERSON, L

HUTCHISON, S

MCVEIGH, K

ODONNELL, R

CHAMPION, S

CARRASQUILLIO, N

FLOYD, J

FREEDLAND, C

HEAGARTY, M

NICHOLAS, S

PRINCE, P

SUAREZ, M

机构：

[1] HARLEM HOSP MED CTR,NEW YORK,NY

[2] CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341

[3] METROPOLITAN HOSP,NEW YORK,NY

[4] NYU,BELLEVUE HOSP CTR,MED CTR,NEW YORK,NY 10016

[5] BRONX LEBANON HOSP CTR,NEW YORK,NY

[6] MT SINAI HOSP,NEW YORK,NY 10029

[7] CTR COMPREHENS HLTH PRACTICE,NEW YORK,NY

[8] NEW YORK CITY DEPT HLTH,NEW YORK,NY 10013

[9] LINCOLN HOSP CTR,NEW YORK,NY

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 1995年 / 142卷 / 07期

关键词：

HIV-1; MATERNAL-FETAL EXCHANGE; POLYMERASE CHAIN REACTION; RISK FACTORS;

D O I：

10.1093/oxfordjournals.aje.a117701

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Four methods of estimating mother-to-child transmission rates of human immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop, were compared in a multicenter New York City prospective cohort study in 1986-1992. Of 833 infants born to women at risk of HIV-1 infection, 388 were born HIV-1 seropositive and 445 were HIV-1 seronegative. The four methods, the Antibody Only, Indirect, Direct, and Virologic Methods, yielded transmission rate estimates of 19-25%, classifying 59-89% of the cohort. Estimation based on persistence of HIV-1 antibody and clinical assessment yielded transmission rates similar to those methods that incorporated virologic testing.

引用

页码：714 / 718

页数：5

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