THE DRUG RESISTANCE-RELATED PROTEIN LRP IS THE HUMAN MAJOR VAULT PROTEIN

被引：563

作者：

SCHEFFER, GL

WIJNGAARD, PLJ

FLENS, MJ

IZQUIERDO, MA

SLOVAK, ML

PINEDO, HM

MEIJER, CJLM

CLEVERS, HC

SCHEPER, RJ

机构：

[1] FREE UNIV AMSTERDAM HOSP,DEPT PATHOL,1081 HV AMSTERDAM,NETHERLANDS

[2] FREE UNIV AMSTERDAM HOSP,DEPT ONCOL,1081 HV AMSTERDAM,NETHERLANDS

[3] ACAD UNIV HOSP UTRECHT,DEPT IMMUNOL,3584 CX UTRECHT,NETHERLANDS

[4] CITY HOPE NATL MED CTR,DEPT CYTOGENET,DUARTE,CA 91010

来源：

NATURE MEDICINE | 1995年 / 1卷 / 06期

关键词：

D O I：

10.1038/nm0695-578

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multidrug-resistant cancer cells frequently overexpress the 110-kD LRP protein (originally named Lung Resistance-related Protein). LRP overexpression has been found to predict a poor response to chemotherapy in acute myeloid leukaemia and ovarian carcinoma. We describe the cloning and chromosome localization of the gene coding for this novel protein. The deduced LRP amino acid sequence shows 87.7% identity with the 104-kD rat major vault protein Vault's are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. The LRP gene is located on chromosome 16, close to the genes coding for multidrug resistance-associated protein and protein kinase C-beta, and may mediate drug resistance, perhaps via a transport process.

引用

页码：578 / 582

页数：5

共 33 条

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