THE 5-HT3 ANTAGONIST, BRL-43694, DOES NOT COMPROMISE THE EFFICACY OF CISPLATIN IN TUMOR-BEARING MICE

被引：6

作者：

GODDARD, PM

JONES, M

POLLARD, LA

VALENTI, MR

HARRAP, KR

机构：

[1] Drug Development Section, The Institute of Cancer Research, Sutton, SM2 5NG, Surrey

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1990年 / 25卷 / 05期

关键词：

D O I：

10.1007/BF00686242

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Binary combinations of cisplatin and the 5-HT3 antagonist, BRL 43694, have been used to treat both conventional mice bearing either L1210 leukaemia or ADJ/PC6 plasmacytoma and nude mice xenografted with a human ovarian carcinoma (HX/110). In no case was there evidence for antagonism by the antiemetic of the antitumour properties of cisplatin. © 1990 Springer-Verlag.

引用

页码：377 / 379

页数：3