ALTERATIONS IN ELASTIN OF THE OPTIC-NERVE HEAD IN HUMAN AND EXPERIMENTAL GLAUCOMA

被引:142
作者
QUIGLEY, HA [1 ]
BROWN, A [1 ]
DORMANPEASE, ME [1 ]
机构
[1] JOHNS HOPKINS UNIV,SCH MED,WILMER INST,GLAUCOMA SERV,BALTIMORE,MD 21205
关键词
D O I
10.1136/bjo.75.9.552
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The optic nerve heads from normal and glaucomatous eyes of humans and monkeys were examined by light and electron microscopy for the presence and distribution of elastin. Elastin densely lined the insertion of the lamina cribrosa into the sclera and was prominent in the laminar beams. The long axis of elastin paralleled that of the collagen fibrils and corresponded to the directions of expected forces on the tissue. In glaucomatous eyes elastin molecules were curled instead of straight and seemed disconnected from the other elements of the connective tissue matrix. Laminar beams stretch and reorganise their substructure during glaucomatous atrophy, probably leading to changed compliance. Differences in elastin function may have a part in susceptibility to glaucomatous injury.
引用
收藏
页码:552 / 557
页数:6
相关论文
共 23 条
  • [1] ANDERSON DR, 1969, ARCH OPHTHALMOL-CHIC, V82, P800
  • [2] GREENE PR, 1980, AM J OPTOM PHYS OPT, V57, P902
  • [3] FINE STRUCTURE OF ELASTIC FIBERS
    GREENLEE, TK
    ROSS, R
    HARTMAN, JL
    [J]. JOURNAL OF CELL BIOLOGY, 1966, 30 (01) : 59 - &
  • [4] EXTRACELLULAR-MATRIX OF THE HUMAN LAMINA CRIBROSA
    HERNANDEZ, MR
    LUO, XX
    IGOE, F
    NEUFELD, AH
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1987, 104 (06) : 567 - 576
  • [5] CHANGES IN THE EXTRACELLULAR-MATRIX OF THE HUMAN OPTIC-NERVE HEAD IN PRIMARY OPEN-ANGLE GLAUCOMA
    HERNANDEZ, MR
    ANDRZEJEWSKA, WM
    NEUFELD, AH
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1990, 109 (02) : 180 - 188
  • [6] HERNANDEZ MR, 1988, INVEST OPHTH VIS SCI, V29, P78
  • [7] EXTRACELLULAR-MATRIX OF THE HUMAN OPTIC-NERVE HEAD
    HERNANDEZ, MR
    IGOE, F
    NEUFELD, AH
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1986, 102 (02) : 139 - 148
  • [8] KAJIKAWA K, 1975, J ELECTRON MICROSC, V24, P287
  • [9] LUNA TECHNIQUE - A BEAUTIFUL STAIN FOR ELASTIN
    KLIGMAN, LH
    [J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1981, 3 (02) : 199 - &
  • [10] MORRISON JC, 1988, INVEST OPHTH VIS SCI, V29, P1141