FIBRINOGEN, FACTOR-VII CLOTTING ACTIVITY AND CORONARY-ARTERY DISEASE SEVERITY

被引：124

作者：

BROADHURST, P

KELLEHER, C

HUGHES, L

IMESON, JD

RAFTERY, EB

机构：

[1] NORTHWICK PK HOSP & CLIN RES CTR,DEPT CARDIOL,DIV CARDIOVASC DIS,WATFORD RD,HARROW HA1 3UJ,MIDDX,ENGLAND

[2] NORTHWICK PK HOSP & CLIN RES CTR,MRC,EPIDEMIOL & MED CARE UNIT,HARROW HA1 3UJ,MIDDX,ENGLAND

[3] CLIN RES CTR,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

ATHEROSCLEROSIS | 1990年 / 85卷 / 2-3期

关键词：

CORONARY ARTERY DISEASE; FACTOR-VII ACTIVITY; FIBRINOGEN;

D O I：

10.1016/0021-9150(90)90108-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess the relationship between fibrinogen, factor VII coagulant (VII(c)) activity and extent of coronary artery disease, we studied 43 white males shown to have > 50% stenosis of at least one major coronary artery. Thirty six had a definite history of myocardial infarction at least 3 months earlier and were classified as having 1, 2 or 3 vessel disease while 7 had 2 or 3 vessel disease, but no prior infarction. Groups were similar with regard to age, body mass index and blood pressure. In those with documented prior infarction, there was a significant relationship between the extent of atheroma and coagulation variables factor VII(c) and fibrinogen. However, given a similar degree of atheroma, patients with prior infarction had significantly higher levels of factor VII(c) activity compared with patients without such a history. These results corroborate those from prospective studies confirming a significant role for the coagulation system in the clinical manifestation of coronary artery disease.

引用

页码：169 / 173

页数：5

共 22 条

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