APPLICATION OF A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY COULOMETRIC METHOD FOR THE ESTIMATION OF MEBENDAZOLE AND ITS METABOLITES IN HUMAN SERA

被引：9

作者：

BETTO, P

GIANBENEDETTI, M

PONTI, F

FERRETTI, R

SETTIMJ, G

GARGIULO, M

LORENZINI, R

机构：

[1] IST SUPER SANITA,CHIM FARMACO LAB,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

[2] OSPED CIVILE TERAMO,I-64100 TERAMO,ITALY

[3] IST SUPER SANITA,MED VET LAB,I-00161 ROME,ITALY

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 563卷 / 01期

关键词：

D O I：

10.1016/0378-4347(91)80282-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel, sensitive high-performance liquid chromatographic method, making use of coulometric detection, for the estimation of mebendazole and its metabolites in the sera of eight hydatidosis patients was devised. Recovery rates, precision, accuracy and sensitivity for each compound are reported and compared with those of the previously published methods.

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页码：115 / 123

页数：9

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