PERGOLIDE PRESYNAPTICALLY INHIBITS CALCIUM-STIMULATED RELEASE OF GAMMA-AMINOBUTYRIC-ACID

被引：18

作者：

DREW, KL ^{[1
]}

UNGERSTEDT, U ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT PHARMACOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

JOURNAL OF NEUROCHEMISTRY | 1991年 / 57卷 / 06期

关键词：

INVIVO MICRODIALYSIS; D2-RECEPTOR; RAT; DORSOLATERAL STRIATUM; GAMMA-AMINOBUTYRIC ACID RELEASE; TETRODOTOXIN;

D O I：

10.1111/j.1471-4159.1991.tb06405.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The release of gamma-aminobutyric acid (GABA) in rat dorsolateral striatum was studied using in vivo microdialysis. Dialysis was conducted 2 days after probe implantation in awake, freely moving rats using a modified Ringer solution. Calcium induced a reversible increase in GABA release that was abolished by tetrodotoxin but was only slightly attenuated by a maximally effective dose of pergolide, a D2 receptor agonist. It was thus concluded that pergolide inhibits calcium-stimulated release of GABA presynaptically by a mechanism distinct from that of tetrodotoxin.

引用

页码：1927 / 1930

页数：4

共 12 条

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