RP-70676 - A POTENT SYSTEMICALLY AVAILABLE INHIBITOR OF ACYL-COA-CHOLESTEROL O-ACYL TRANSFERASE (ACAT)

被引：31

作者：

ASHTON, MJ

BRIDGE, AW

BUSH, RC

DRON, DI

HARRIS, NV

JONES, GD

LYTHGOE, DJ

RIDDELL, D

SMITH, C

机构：

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80149-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

RP 70676 (3d) is a potent inhibitor of ACAT. It is an effective hypocholesterolaemic agent in the cholesterol-fed rabbit, and reduces the accumulation of both cholesterol and cholesterol ester in rabbit aorta and thoracic artery. The compound is readily bioavailable in rabbits with significant levels of parent compound present in plasma up to 6 hours after an oral dose.

引用

页码：375 / 380

页数：6

共 8 条

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