PATHOPHYSIOLOGY OF SPINAL-CORD TRAUMA

被引：208

作者：

ANDERSON, DK

HALL, ED

机构：

[1] Department of Veterans Affairs Medical Center, Departments of Neurology and Physiology/Biophysics, University of Cincinnati College of Medicine, OH

[2] CNS Diseases Research, The Upjohn Company, Kalamazoo, MI

来源：

ANNALS OF EMERGENCY MEDICINE | 1993年 / 22卷 / 06期

关键词：

TRAUMA; SPINAL CORD;

D O I：

10.1016/S0196-0644(05)82739-8

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This article reviews the pathophysiology of spinal cord injury. The focus is on the role of post-traumatic membrane lipid changes, including lipid hydrolysis with enzymatic lipid peroxidation (ie, eicosanoid production) and nonenzymatic, free radical-induced lipid peroxidation in the secondary autodestruction of injured spinal cord tissue. A speculative etiopathogenesis of secondary injury is presented in an attempt to explain the importance and order of the pathophysiologic events that result in tissue death and the apparent effectiveness of diverse pharmacologic agents in the treatment of experimental spinal cord injury.

引用

页码：987 / 992

页数：6

共 91 条

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