REDUCTION IN VISCOSITY OF CYSTIC-FIBROSIS SPUTUM IN-VITRO BY GELSOLIN

被引：161

作者：

VASCONCELLOS, CA

ALLEN, PG

WOHL, ME

DRAZEN, JM

JANMEY, PA

STOSSEL, TP

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,DIV EXPTL MED,BOSTON,MA 02115

[2] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT PEDIAT,DIV RESP MED,BOSTON,MA 02115

[3] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,DIV RESP MED,BOSTON,MA 02115

来源：

SCIENCE | 1994年 / 263卷 / 5149期

关键词：

D O I：

10.1126/science.8310295

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obstruction of airways by viscous sputum causes lung damage in patients with cystic fibrosis (CF). Sputum samples from OF patients were shown to contain filamentous actin. Human plasma gelsolin, a protein that severs actin filaments, rapidly decreased the viscosity of CF sputum samples in vitro. Gc globulin and deoxyribonuclease I, proteins that sequester monomeric actin but do not sever actin filaments, were less efficient than gelsolin in diminishing sputum viscosity. These results suggest that gelsolin may have therapeutic potential as a mucolytic agent in CF patients.

引用

页码：969 / 971

页数：3

共 36 条

[1] RECOMBINANT HUMAN DNASE INHALATION IN NORMAL SUBJECTS AND PATIENTS WITH CYSTIC-FIBROSIS - A PHASE-1 STUDY [J].