BDNF-MEDIATED RESCUE OF AXOTOMIZED MOTOR-NEURONS DECREASES WITH INCREASING DOSE

被引:46
作者
VEJSADA, R
SAGOT, Y
KATO, AC
机构
[1] Division of Clinical Neurophysiology, Department of Pharmacology, Centre MÉdical Universitaire, Geneva, CH-1211
关键词
AXOTOMY; BDNF; MOTOR NEURON RESCUE; NEURONAL DEATH; NEUROTROPHINS;
D O I
10.1097/00001756-199410000-00012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
DIRECT application of brain-derived neurotrophic factor (BDNF) to the cut end of axotomized immature motor neurones had only transient survival-promoting effects. Therefore, we have examined whether additional delivery of BDNF with repeated subcutaneous injections (1 mg/ml) could potentiate this short-term rescue of the lesioned sciatic and facial motor neurones in neonatal rats. Direct application of BDNF combined with intermittent (3-day intervals) injections slightly improved motor neurone survival. However, when BDNF was injected daily in addition to the direct application, the number of surviving lesioned motor neurones was markedly reduced. These findings, corroborated by results in embryonic spinal cord cultures, show that a dose-dependent reversal of BDNF-mediated positive effects on motor neurones occurs in vivo.
引用
收藏
页码:1889 / 1892
页数:4
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