INCREASED SERUM D-LACTATE ASSOCIATED WITH DIABETIC-KETOACIDOSIS

被引：60

作者：

CHRISTOPHER, MM

BROUSSARD, JD

FALLIN, CW

DROST, NJ

PETERSON, ME

机构：

[1] UNIV FLORIDA,DEPT PHYSIOL SCI,GAINESVILLE,FL 32610

[2] ANIM MED CTR,NEW YORK,NY

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1995年 / 44卷 / 03期

关键词：

D O I：

10.1016/0026-0495(95)90156-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We hypothesized that serum D-lactate may be increased in vivo in diabetes mellitus as a result of increased glucose flux through the glyoxalase pathway and/or via hepatic ketone metabolism. Levels of D-lactate and related metabolic intermediates were measured in 30 cats with spontaneous diabetes mellitus and in one ketoacidotic nondiabetic cat. Serum D-lactate was significantly (P = .0051) elevated in cats with ketoacidosis (337.2 +/- 70.2 mu mol/L) as compared with nonketoacidotic diabetic (140.3 +/- 58.8) and control (25.0 +/- 6.5) cats. Two nonketoacidotic cats also had high levels of D-lactate. There was a significant linear correlation (r = .684, P = .0001) between D-lactate and beta-hydroxybutyrate concentrations. Serum D-lactate did not correlate with serum glucose (r = .078, P = .6825), and in vitro erythrocyte D-lactate formation did not increase in the presence of hyperglycemia. These data suggest that hepatic ketone metabolism, rather than hyperglycemia, may be a major source of serum D-lactate in diabetics. Copyright (C) 1995 by W.B. Saunders Company

引用

页码：287 / 290

页数：4

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