CHLORIDE CHANNELS OF INTRACELLULAR ORGANELLES

被引：97

作者：

ALAWQATI, Q

机构：

[1] Q Al-Awqati, College of Physicians and Surgeons, Columbia University, New York, NY 10032

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 04期

关键词：

D O I：

10.1016/0955-0674(95)80006-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula facilitate the efflux of Ca2+. In the Golgi and some endosomes, the open Cl- channels (probably the cystic fibrosis transmembrane conductance regulator) favor accumulation of H+.

引用

页码：504 / 508

页数：5

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