THE NATURAL-HISTORY AND ASSOCIATIONS OF MICROALBUMINURIA IN TYPE-2 DIABETES DURING THE 1ST YEAR AFTER DIAGNOSIS

被引：51

作者：

PATRICK, AW

LESLIE, PJ

CLARKE, BF

FRIER, BM

机构：

[1] Diabetic Department, Royal Infirmary, Edinburgh

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 10期

关键词：

Diabetic complications; Glycosylated haemoglobin; Microalbuminuria; Nephropathy; Type; 2; diabetes; Vascular disease;

D O I：

10.1111/j.1464-5491.1990.tb01326.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of microalbuminuria was assessed in 149 consecutive, newly‐diagnosed and untreated patients with Type 2 diabetes, 129 of whom were followed up for 1 year, with at least three urine specimens being obtained during this period. At initial presentation, 39 (26%) patients had a urinary albumin to creatinine ratio (ACR) of > 2.5 mg mmol−1 and compared with patients who had a normal ACR, they were older (64 (11) (SD) vs 58 (11) yr, p < 0.002), with higher random blood glucose (14.4 (4.5) vs 12.3 (4.4) mmol l−1, p < 0.02) and glycosylated haemoglobin (13.0 (3.1) vs 11.3 (2.7)%, p < 0.01) concentrations. An elevated ACR was also associated with a higher systolic blood pressure (149 (22) vs 140 (22), p < 0.05) and the presence of macrovascular disease, particularly peripheral vascular disease (p < 0.001), with this association persisting after adjustment for the effect of age. Ten patients reverted to normal albumin excretion on improving blood glucose control, this group having a significantly higher glycosylated haemoglobin concentration at initial presentation than the group with a persistently elevated ACR (14.4 (2.5) vs 12.0 (3.0)%, p < 0.05). The 21 (16%) patients with a persistently elevated ACR from diagnosis of Type 2 diabetes were older than those with normal albumin excretion throughout (64 (7) vs 58 (10) yr, p < 0.02) and it is probable that these patients have abnormal albumin excretion secondary to established renal pathology. 1990 Diabetes UK

引用

页码：902 / 908

页数：7

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