A SAUVAGINE CORTICOTROPIN-RELEASING FACTOR-RECEPTOR EXPRESSED IN HEART AND SKELETAL-MUSCLE

被引：361

作者：

KISHIMOTO, T

PEARSE, RV

LIN, CJR

ROSENFELD, MG

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,BIOMED SCI GRAD PROGRAM,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,SCH MED,HOWARD HUGHES MED INST,LA JOLLA,CA 92093

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 04期

关键词：

UROTENSIN I; 7 TRANSMEMBRANE DOMAIN; ALPHA-HELICAL CORTICOTROPIN-RELEASING FACTOR-(9-41);

D O I：

10.1073/pnas.92.4.1108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Corticotropin-releasing factor (CRF) mediates many critical aspects of the physiological response to stress. These effects are elicited by binding to specific high-affinity receptors, which are coupled to guanine nucleotide stimulatory factor (G(s))-response pathways. Recently, a gene encoding a receptor for CRF, expressed in pituitary and the central nervous system (PC-CRF receptor), was isolated and characterized. Here we report the identification and characterization of a second, distinct CRF receptor that is expressed primarily in heart and skeletal muscle and exhibits a specific ligand preference and antagonist sensitivity compared with the PC-CRF receptor. We refer to this second receptor as the heart/muscle (HM)-CRF receptor.

引用

页码：1108 / 1112

页数：5

共 39 条

[1] GLUCOCORTICOIDS INHIBIT CORTICOTROPIN-RELEASING FACTOR-INDUCED PRODUCTION OF ADENOSINE-3',5'-MONOPHOSPHATE IN CULTURED ANTERIOR-PITUITARY CELLS [J].