IN-SITU HYBRIDIZATION TO INTERPHASE NUCLEI IN ACUTE-LEUKEMIA

被引:38
作者
ROMANA, SP
CHERIF, D
LECONIAT, M
DERRE, J
FLEXOR, MA
BERGER, R
机构
[1] IGM,INSERM,U301,27 RUE JULIETTE DODU,F-75010 PARIS,FRANCE
[2] INST GENET MOLEC,CNRS,SDI 159541,PARIS,FRANCE
关键词
D O I
10.1002/gcc.2870080206
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Numerical chromosome abnormalities were studied in 17 acute lymphoblastic leukemias and one hyperdiploid acute myeloblastic leukemia by fluorescence in situ hybridization (FISH) using YAC clones specific to chromosomes 21 and 6. The results agreed well with cytogenetic findings. Hyperdiploid leukemias with more than 50 chromosomes usually had 4 copies of chromosome 21 and three of chromosome 6, while diploid and pseudodiploid cases were confirmed to have two copies of the two chromosomes. Interesting discrepancies were also observed. In one patient, trisomy 6 was detected by FISH but not by cytogenetics because of the probable inclusion of a chromosome 6 segment within a marker chromosome. The percentages of nuclei with 3 or 4 spots (chromosome 21) and three spots (chromosome 6) in hyperdiploid cells were significantly different in some patients, whereas they might be identical from cytogenetic data. (C) 1993 Wiley-Liss, Inc.
引用
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页码:98 / 103
页数:6
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