THE EFFECTS OF SUMATRIPTAN ON PITUITARY SECRETION IN MAN

被引:28
作者
FRANCESCHINI, R
CATALDI, A
GARIBALDI, A
CIANCIOSI, P
SCORDAMAGLIA, A
BARRECA, T
ROLANDI, E
机构
[1] Department of Internal Medicine, Viale Benedetto XV, n. 6 University of Genoa, 161 32, Genoa
关键词
5-HYDROXYTRYPTAMINE; SUMATRIPTAN; CYPROHEPTADINE; PITUITARY SECRETION; GROWTH HORMONE;
D O I
10.1016/0028-3908(94)90014-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sumatriptan, a new antimigraine drug with high affinity and selectivity for certain 5-hydroxytryptamine (5-HT1D) receptor subtypes, was administered to 12 normal subjects, in order to investigate the effects of 5-HT receptor activation on anterior pituitary secretion. Sumatriptan increased plasma growth hormone (GH) levels from 2.5 +/- 0.5 mIU/1 in basal conditions to 17.3 +/- 2.6 mIU/1 30 min after administration of the drug. After pre-treatment with cyproheptadine, an anti-serotoninergic drug known to inhibit GH secretion, the mean integrated sumatriptan-induced GH response decreased from 14.8 +/- 3.9 mIU/1*hr to 3.7 +/- 1.7 mIU/1*hr. Sumatriptan administration did not have any effect on the secretion of the other anterior pituitary hormones. It is concluded that sumatriptan selectively increases GH secretion in man, but the exact nature of the receptors involved is not yet known.
引用
收藏
页码:235 / 239
页数:5
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