GROWTH-INHIBITION AND REGRESSION OF HUMAN PROSTATE AND BREAST-TUMORS IN ATHYMIC MICE BY TEA EPIGALLOCATECHIN GALLATE

被引:265
作者
LIAO, SS
UMEKITA, Y
GUO, JT
KOKONTIS, JM
HIIPAKKA, RA
机构
[1] The Ben May Institute, Department of Biochemistry and Molecular Biology, Cancer Research Center, Chicago
关键词
PROSTATE CANCER; BREAST CANCER; GREEN TEA; (-)EPIGALLOCATECHIN-3-GALLATE; POLYPHENOL; CANCER CHEMOPREVENTION;
D O I
10.1016/0304-3835(95)03948-V
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The human prostate cancer cell lines, PC-3 (androgen-insensitive) and LNCaP 104-R (androgen-repressed) were inoculated subcutaneously into nude mice to produce prostate tumors. Intraperitoneal injection of green tea (-)epigallocatechin-3-gallate but not structurally related catechins, such as (-)epicatechin-3-gallate, inhibited the growth and rapidly reduced the size of human prostate tumors in nude mice. (-)Epigallocatechin-3-gallate also rapidly inhibited the growth of tumor growth formed by the human mammary cancer cell line MCF-7 in nude mice. It is possible that there is a relationship between the high consumption of green tea and the low incidence of prostate and breast cancers in some Asian countries.
引用
收藏
页码:239 / 243
页数:5
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